Publications from the lab.

1996-2000      2001-2005      2006-2010       2011       Reviews and Methods



 Prinos P., Garneau D., Boivin M., Gendron D., Lucier J.-F., Tremblay K., Brosseau J.-P., Couture S., Lapointe E., Thibault P., Gervais-Bird J., Venables J., Klinck R., Chabot B., Perreault J.-P., Wellinger R.J. and Abou-Elela S. (2011)
Tumor Associated Alternative Splicing Events Promote Cell Survival.
Nature Structural and Molecular Biology (In Press)


PDF Noël J.-F. and Wellinger R.J. (2011).
Abrupt telomere losses and reduced end-resection can explain accelerated senescence of Smc5/6 mutants lacking telomerase.
DNA Repair 10: 271-282


PDF Leduc F., Faucher D., Bikond-Nkoma G., Grégoire M.-C., Arguin M., Wellinger R.J. and Boissonneault G. (2011).
Genome-Wide Mapping of DNA Strand Breaks.
PLoS ONE 6(2): e17353.doi:10.1371/journal.pone.0017353


PDF Faucher D. and Wellinger R.J. (2010).
Methylated H3K4, a transcription associated histone modification, is involved in the DNA damage response pathway.
PLoS Genetics.6(8). pii: e1001082


PDF Vodenicharov M.D., Laterreur N. and Wellinger R.J. (2010).
Telomere capping in non-dividing yeast cells requires Yku and Rap1.
EMBO Journal Epub July 13, 2010;doi:10.1038/emboj.2010.155


PDF Toussaint M., Wellinger R.J. and Conconi A. (2010).
Differential participation of nucleotide excision repair and homologous recombination in yeast responses
to ultraviolet light radiation.
Mutation Research 698: 52-59


PDF Gunisova S., Elhanan E., Nosek J., Gorkovoy V., Brown Y., Lucier J.-F., Laterreur N., Wellinger R.J.*,
Tzfati Y.*, and Tomaska L.* (2009).
Identification and comparative analysis of telomerase RNAs from Candida species reveal conservation
of functional elements.
RNA 15 546-59.(*Co-PIs)


PDF Knecht H., Sawan B., LichtensztejnD., Lemieux B., Wellinger R.J. and Mai S. (2009).
The 3D Nuclear Organization of Telomeres Marks the Transition from Hodgkin to Reed-Sternberg Cells.
Leukemia 23:565-573 

PDF Klinck R., Bramard A., Inkel L., Dufresne-Martin G., Gervais-Bird J., Madden R., Paquet E.R., Prinos P.,
Jilaveanu-Pelmus M., Rancourt C., Wellinger R.J., Chabot B. and Abou Elela S. (2008).
An Integrated System for the Discovery of Ovarian Cancer-Associated Splicing Patterns.
Cancer Research 68(3):657-63. 

PDF Gallardo F., Olivier C., Dandjinou A., Wellinger R.J. and Chartrand P. (2008).  
 A Crm1p-dependent pathway excludes misassembled telomerase from the nucleus.
EMBO J 27:748-757
 
PDF Parenteau J., Durand M., Véronneau S., Lacombe A.-A., Morin G., Guérin V., Cecez B., Gervais-Bird J.,
Koh C.-S., Brunelle D., Wellinger R.J.*, Chabot B.* and Abou Elela S*. (2008).
Systematic deletion of many yeast introns reveals a minority of genes that require splicing for function.
Molecular Biology of the Cell 19:1932-1941  (*Co-PIs)
 
PDF Venables J.P., Klinck R., Bramard A., Inkel L., Dufresne-Martin G., Koh C.-S., Gervais-Bird J., Lapointe E.,
Froehlich U., Durand M., Gendron D., Brosseau J.-P., Thibault P., Lucier J.-F., Tremblay K., Prinos P.,
Wellinger R.J., Chabot B., Rancourt C. and Abou Elela S. (2008).
Identification of Alternative Splicing Markers for Breast Cancer.
Cancer Research  68: 9525-9531

PDF Larose S., Laterreur N., Ghazal G., Gagnon J., Wellinger R.J. and Abou-Elela S. (2007).
RNase III-dependent regulation of yeast telomerase.
J. Biol. Chemistry 282(7):4373-81. 

PDF Berthiau A.-S., Yankulov K., Bah A., Revardel E., Wellinger R.J., Géli V. and Gilson É. (2006).
Subtelomeric proteins negatively regulate telomere elongation in budding yeast: evidence for an antagonism between
transcriptional activators and telomerase.
EMBO Journal 25: 846-856 
 
PDF Larrivée M. and Wellinger R.J. (2006).
Telomerase- and Capping independent yeast survivors with alternate telomere states.
Nature Cell Biology 8, 741-747
 
PDF Toussaint M., Levasseur G., Gervais-Bird J., Wellinger R.J., Abou Elela S., Conconi A. (2006).
A high-throughput method to measure the sensitivity of yeast cells to genotoxic agents in liquid cultures.
Mutation Research 606(1-2):92-105.
 
PDF Vodenicharov M.D. and Wellinger R.J. (2006).
DNA-degradation at unprotected telomeres in yeast is regulated by the CDK1 (CDC28/Clb) cell cycle kinase.
Molecular Cell 24, 127-137  

PDF Chakhparonian M., Faucher D. and Wellinger R.J. (2005).
A new yeast TEL1-allele with differential effects on the DNA damage TM-checkpoint and telomere maintenance.
Current Genetics 48(5); 310-322 
 
PDF Parenteau J., Klinck R., Good L., Langel U., Wellinger R.J.* and Abou Elela S.* (2005).
Free uptake of cell-penetrating peptides by fission yeast.
FEBS Letters 579(21); 4873-4878 (*Co-PIs)  

PDF Toussaint M., Dionne I. and Wellinger R.J. (2005).  
Limited TTP-supply affects telomere length in a telomerase-independent fashion.
Nucleic Acids Research 33(2); 703-714

PDF Patry C., Lemieux B., Wellinger R.J.* and Chabot B.* (2004).
Targeting hnRNP A1 and A2 by RNA interference promotes cell death in transformed but not normal mouse cell lines.
Molecular Cancer Therpeutics 3(10), 1193-1199  (*: Co-PIs)

PDF Larrivée M., LeBel C. and Wellinger R.J. (2004).
The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX-complex.
Genes and Development 18, (no 12, June 15, 2004)

PDF  Bah A., Bachand F., Clair E., Autexier C. and Wellinger R.J. (2004).
Humanized telomeres and an attempt of expressing a functional human telomerase in yeast.
Nucleic Acids Res. 32, 1917-1927

PDF  Dandjinou A.T., Lévesque N., Larose S., Lucier J.-F., Abou Elela S. and Wellinger R.J. (2004).
A phylogenetically based secondary structure for the yeast telomerase RNA.
Current Biology 14 (no 13, July 2004; published online May 27, 2004)

pdf Patry C., Bouchard L., Labrecque P., Gendron D., Lemieux B., Toutant J., Lapointe E., Wellinger R.J.* and Chabot B.* (2003).
siRNA-mediated reduction in hnRNP A1/A2 proteins induces apoptosis in human cancer cells but not in normal mortal cell lines.
Cancer Research 63(22), 7679-7688  (*: Co-PIs)

PDF Gravel S. and Wellinger R.J. (2002).
Maintenance of double-stranded telomeric repeats as the critical determinant for cell viability in yeast cells lacking Ku.
Mol. Cell. Biol. 22, 2182-2193

PDF  Parenteau J. and Wellinger R.J. (2002).
Differential processing of leading and lagging-strand ends at Saccharomyces cerevisiae telomeres revealed by the absence of Rad27p nuclease.
Genetics 162, 1583-1594

pdf Driller L., Wellinger R.J., Larrivée M., Kremmeri E., Jaklin S. and Feldmann H.M. (2000)
A Short C-terminal Domain of Yku70p Is Essential for Telomere Maintenance.
Journal of Biological Chemistry 275: 24921–24927

PDF  Adams Martin A.*, Dionne I.*, Wellinger R.J. and Holm C. (2000).
The function of DNA polymerase at telomeric G-tails is important for telomere homeostasis.
Mol. Cell. Biol. 20, 786-796.  (*: Co-first Authors)

PDF Parenteau J. and Wellinger R.J. (1999).
Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27.
Mol. Cell. Biol. 19, 4143-4152.

pdf  La Branche H., Dupuis S., Ben-David Y., Bani M.-R., Wellinger R.J. and Chabot B. (1998).
Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase.
Nature Genetics 19, 199-202.

pdf  Gravel S., Larrivée M., Labrecque P. and Wellinger R.J. (1998).
Yeast Ku as a regulator of chromosomal end-structure.
Science 280, 741-744.

pdf  Dionne I. and Welinger R.J. (1998).
Processing of telomeric DNA ends requires the passage of a replication fork.
Nucleic Acids Research 26, 5365-5371.

pdf McElligott R. and Wellinger R.J. (1997).
The terminal DNA structures of mammalian chromosomes.
EMBO Journal 16, 3705-3714.

pdf  Wellinger R.J., Ethier K., Labrecque P. and Zakian V.A. (1996).
Evidence for a new step in telomere maintenance.
Cell 85, 423-433.

pdf  Dionne I. and Wellinger R.J. (1996).
Cell cycle regulated generation of single stranded G-rich DNA in the absence of telomerase.
Proc. Natl. Acad. Sci. USA 93, 13902-13907.



PDF  Wellinger R.J. (2010).
When the caps fall off: Responses to telomere uncapping in yeast.
FEBS Letters 584(17):3734-40


PDF  Wellinger R.J. (2009).
The CST complex and Telomere maintenance: the exception becomes the rule.
Molecular Cell 36: 168-169


pdf Vodenicharov M and Wellinger R.J. (2007)
The Cell Division Cycle Puts Up with Unprotected Telomeres.
Cell Cycle 6: 1161-1167

pdf  LeBel C., Larrivée M., Bah A., Laterreur N., Lévesque N. and Wellinger R.J.(2006).
Telomere assays. In: Yeast Protocols:
Methods in Cell and Molecular Biology 2nd Edition; W Xiao(ed)., The Humana Press

pdf Dandjinou A., Larrivée M. and Wellinger R.J. (2006).
Two dimensional agarose gel electrophoresis. In: Yeast Protocols:
Methods in Cell and Molecular Biology 2nd Edition; W Xiao(ed)., The Humana Press

PDF (Poster ) LeBel C. and Wellinger R.J. (2005).
Telomeres: what`s new at your end?
J Cell Science 118: 2785-2788

 pdf  LeBel C. and Wellinger R.J. (2004).
Structure terminale des chromosomes: le "capuchon télomérique".
Médecine/Science 20:207-212

 pdf  Chakhparonian M. and Wellinger R.J. (2003).
Telomere maintenance and DNA replication: how closely are these two connected?
Trends in Genetics 19(8):439-446

pdf Conconi A. and Wellinger R.J. (2003).
A new link for a linker histone.
Mol. Cell 11(6):1421-1423.

pdf Wellinger R.J. and Sen D. (1997).
The DNA structures at the ends of eukaryotic chromosomes.
Eur. J. Cancer 33(5), 735-749.