ID AGTR1_HUMAN Reviewed; 359 AA. AC P30556; Q13725; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 04-NOV-2008, entry version 86. DE RecName: Full=Type-1 angiotensin II receptor; DE AltName: Full=AT1; DE AltName: Full=AT1AR; DE AltName: Full=AT1BR; GN Name=AGTR1; Synonyms=AGTR1A, AGTR1B, AT2R1, AT2R1B; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=92337608; PubMed=1378723; DOI=10.1016/S0006-291X(05)80804-6; RA Mauzy C.A., Hwang O., Egloff A.M., Wu L.H., Chung F.-Z.; RT "Cloning, expression, and characterization of a gene encoding the RT human angiotensin II type 1A receptor."; RL Biochem. Biophys. Res. Commun. 186:277-284(1992). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Lymphocyte; RX MEDLINE=92181475; PubMed=1543512; DOI=10.1016/0006-291X(92)91600-U; RA Furuta H., Guo D.F., Inagami T.; RT "Molecular cloning and sequencing of the gene encoding human RT angiotensin II type 1 receptor."; RL Biochem. Biophys. Res. Commun. 183:8-13(1992). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Liver; RX MEDLINE=92231907; PubMed=1567413; DOI=10.1016/S0006-291X(05)80288-8; RA Bergsma D.J., Ellis C., Kumar C., Nuthalaganti P., Kersten H., RA Elshourbagy N.A., Griffin E., Stadel J.M., Aiyar N.; RT "Cloning and characterization of a human angiotensin II type 1 RT receptor."; RL Biochem. Biophys. Res. Commun. 183:989-995(1992). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Liver; RX MEDLINE=92198490; PubMed=1550596; DOI=10.1016/0006-291X(92)90570-B; RA Takayanagi R., Ohnaka K., Sakai Y., Nakao R., Yanase T., Haji M., RA Inagami T., Furuta H., Gou D.F., Nakamuta M., Nawata H.; RT "Molecular cloning, sequence analysis and expression of a cDNA RT encoding human type-1 angiotensin II receptor."; RL Biochem. Biophys. Res. Commun. 183:910-916(1992). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=92375105; PubMed=1508224; DOI=10.1210/me.6.7.1113; RA Curnow K.M., Pascoe L., White P.C.; RT "Genetic analysis of the human type-1 angiotensin II receptor."; RL Mol. Endocrinol. 6:1113-1118(1992). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT TRP-289. RC TISSUE=Placenta; RX MEDLINE=94183213; PubMed=8135787; DOI=10.1006/bbrc.1994.1252; RA Konishi H., Kuroda S., Inada Y., Fujisawa Y.; RT "Novel subtype of human angiotensin II type 1 receptor: cDNA cloning RT and expression."; RL Biochem. Biophys. Res. Commun. 199:467-474(1994). RN [7] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Liver; RX MEDLINE=95313084; PubMed=7792812; DOI=10.1016/0039-128X(94)00022-5; RA Nawata H., Takayanagi R., Ohnaka K., Sakai Y., Imasaki K., Yanase T., RA Ikuyama S., Tanaka S., Ohe K.; RT "Type 1 angiotensin II receptors of adrenal tumors."; RL Steroids 60:28-34(1995). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Placenta; RA Ostermann E., Castanon M.J.; RT "Cloning and sequencing of a human cDNA encoding the angiotensin II RT receptor type 1."; RL Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Antonellis A., Rogus J.J., Pezzolesi M.G., Makita Y., Nam M., RA Doria A., Warram J.H., Krolewski A.S.; RT "Rapid identification of polymorphisms in genomic DNA: a high density RT SNP map of the type I angiotensin II receptor gene locus on chromosome RT 3q."; RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Kopatz S.A., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. RN [11] RP VARIANT RTD MET-282. RX PubMed=16116425; DOI=10.1038/ng1623; RA Gribouval O., Gonzales M., Neuhaus T., Aziza J., Bieth E., Laurent N., RA Bouton J.M., Feuillet F., Makni S., Ben Amar H., Laube G., RA Delezoide A.-L., Bouvier R., Dijoud F., Ollagnon-Roman E., Roume J., RA Joubert M., Antignac C., Gubler M.-C.; RT "Mutations in genes in the renin-angiotensin system are associated RT with autosomal recessive renal tubular dysgenesis."; RL Nat. Genet. 37:964-968(2005). CC -!- FUNCTION: Receptor for angiotensin II. Mediates its action by CC association with G proteins that activate a phosphatidylinositol- CC calcium second messenger system. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Liver, lung, adrenal and adrenocortical CC adenomas. CC -!- PTM: C-terminal Ser or Thr residues may be phosphorylated. CC -!- DISEASE: Defects in AGTR1 are a cause of renal tubular dysgenesis CC (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder CC of renal tubular development characterized by persistent fetal CC anuria and perinatal death, probably due to pulmonary hypoplasia CC from early-onset oligohydramnios (the Potter phenotype). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC -!- WEB RESOURCE: Name=GeneReviews; CC URL="http://www.genetests.org/query?gene=AGTR1"; CC -!- WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and CC polymorphism database; CC URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=AGTR1"; CC -!- WEB RESOURCE: Name=Wikipedia; Note=Angiotensin receptor entry; CC URL="http://en.wikipedia.org/wiki/Angiotensin_receptor"; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M91464; AAA35569.1; -; Genomic_DNA. DR EMBL; Z11162; CAA77513.1; -; Genomic_DNA. DR EMBL; M87290; AAA35535.1; -; mRNA. DR EMBL; S77410; AAB34644.1; -; mRNA. DR EMBL; M93394; AAA58370.1; -; mRNA. DR EMBL; D13814; BAA02968.1; -; mRNA. DR EMBL; X65699; CAA46621.1; -; mRNA. DR EMBL; AF245699; AAF70464.1; -; Genomic_DNA. DR EMBL; AY221090; AAO65968.1; -; Genomic_DNA. DR PIR; I39418; I39418. DR PIR; JC1104; JC1104. DR RefSeq; NP_000676.1; -. DR RefSeq; NP_004826.2; -. DR RefSeq; NP_033611.1; -. DR RefSeq; NP_114038.1; -. DR RefSeq; NP_114438.1; -. DR UniGene; Hs.477887; -. DR UniGene; Hs.705369; -. DR PDB; 1ZV0; Model; -; B=1-359. DR PDBsum; 1ZV0; -. DR PhosphoSite; P30556; -. DR Ensembl; ENSG00000144891; Homo sapiens. DR GeneID; 185; -. DR KEGG; hsa:185; -. DR H-InvDB; HIX0003757; -. DR HGNC; HGNC:336; AGTR1. DR HPA; HPA003596; -. DR MIM; 106165; gene. DR MIM; 267430; phenotype. DR Orphanet; 3033; Renal tubular dysgenesis. DR PharmGKB; PA43; -. DR HOGENOM; P30556; -. DR HOVERGEN; P30556; -. DR DrugBank; DB00796; Candesartan. DR DrugBank; DB00876; Eprosartan. DR DrugBank; DB01342; Forasartan. DR DrugBank; DB01029; Irbesartan. DR DrugBank; DB00678; Losartan. DR DrugBank; DB00275; Olmesartan. DR DrugBank; DB01347; Saprisartan. DR DrugBank; DB00421; Spironolactone. DR DrugBank; DB01349; Tasosartan. DR DrugBank; DB00966; Telmisartan. DR DrugBank; DB00177; Valsartan. DR NextBio; 752; -. DR ArrayExpress; P30556; -. DR CleanEx; HS_AGTR1; -. DR GermOnline; ENSG00000144891; Homo sapiens. DR GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc. DR GO; GO:0001596; F:angiotensin type I receptor activity; IDA:UniProtKB. DR GO; GO:0004945; F:angiotensin type II receptor activity; NAS:UniProtKB. DR GO; GO:0031711; F:bradykinin receptor binding; IPI:UniProtKB. DR GO; GO:0046982; F:protein heterodimerization activity; IPI:UniProtKB. DR GO; GO:0019722; P:calcium-mediated signaling; IDA:UniProtKB. DR GO; GO:0051482; P:elevation of cytosolic calcium ion concentr...; IDA:UniProtKB. DR GO; GO:0001822; P:kidney development; IMP:UniProtKB. DR GO; GO:0006800; P:oxygen and reactive oxygen species metaboli...; TAS:UniProtKB. DR GO; GO:0050729; P:positive regulation of inflammatory response; TAS:UniProtKB. DR GO; GO:0033864; P:positive regulation of NAD(P)H oxidase activity; TAS:UniProtKB. DR GO; GO:0002034; P:regulation of blood vessel size by renin-an...; IC:UniProtKB. DR GO; GO:0001558; P:regulation of cell growth; NAS:UniProtKB. DR GO; GO:0042127; P:regulation of cell proliferation; NAS:UniProtKB. DR GO; GO:0003078; P:regulation of natriuresis; NAS:UniProtKB. DR GO; GO:0019229; P:regulation of vasoconstriction; IDA:UniProtKB. DR GO; GO:0042312; P:regulation of vasodilation; IC:UniProtKB. DR GO; GO:0002018; P:renin-angiotensin regulation of aldosterone...; NAS:UniProtKB. DR InterPro; IPR000190; ATII_AT1_rcpt. DR InterPro; IPR000248; ATII_rcpt. DR InterPro; IPR001186; BK_rcpt_B1. DR InterPro; IPR001277; CXC_4_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_supfam. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00241; ANGIOTENSINR. DR PRINTS; PR00635; ANGIOTENSN1R. DR PRINTS; PR00993; BRADYKINNB1R. DR PRINTS; PR00645; CXCCHMKINER4. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 1: Evidence at protein level; KW 3D-structure; Cell membrane; Disease mutation; KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; KW Palmitate; Phosphoprotein; Polymorphism; Receptor; Transducer; KW Transmembrane. FT CHAIN 1 359 Type-1 angiotensin II receptor. FT /FTId=PRO_0000069153. FT TOPO_DOM 1 27 Extracellular (Potential). FT TRANSMEM 28 52 1 (Potential). FT TOPO_DOM 53 64 Cytoplasmic (Potential). FT TRANSMEM 65 87 2 (Potential). FT TOPO_DOM 88 102 Extracellular (Potential). FT TRANSMEM 103 124 3 (Potential). FT TOPO_DOM 125 142 Cytoplasmic (Potential). FT TRANSMEM 143 162 4 (Potential). FT TOPO_DOM 163 192 Extracellular (Potential). FT TRANSMEM 193 214 5 (Potential). FT TOPO_DOM 215 240 Cytoplasmic (Potential). FT TRANSMEM 241 262 6 (Potential). FT TOPO_DOM 263 275 Extracellular (Potential). FT TRANSMEM 276 296 7 (Potential). FT TOPO_DOM 297 359 Cytoplasmic (Potential). FT LIPID 355 355 S-palmitoyl cysteine (Potential). FT CARBOHYD 4 4 N-linked (GlcNAc...) (Potential). FT CARBOHYD 176 176 N-linked (GlcNAc...) (Potential). FT CARBOHYD 188 188 N-linked (GlcNAc...) (Potential). FT DISULFID 101 180 By similarity. FT VARIANT 48 48 L -> V (in dbSNP:rs2011425). FT /FTId=VAR_011846. FT VARIANT 163 163 A -> T (in dbSNP:rs12721226). FT /FTId=VAR_029206. FT VARIANT 244 244 A -> S (in dbSNP:rs12721225). FT /FTId=VAR_029207. FT VARIANT 282 282 T -> M (in RTD). FT /FTId=VAR_035086. FT VARIANT 289 289 C -> W (in dbSNP:rs1064533). FT /FTId=VAR_011847. FT VARIANT 336 336 T -> P (in dbSNP:rs1801021). FT /FTId=VAR_011848. FT CONFLICT 187 187 Q -> R (in Ref. 6; BAA02968). FT CONFLICT 204 205 FL -> SC (in Ref. 6; BAA02968). FT CONFLICT 232 232 K -> N (in Ref. 6; BAA02968). FT CONFLICT 240 240 K -> R (in Ref. 6; BAA02968). FT CONFLICT 268 268 L -> Q (in Ref. 6; BAA02968). FT CONFLICT 311 313 RYF -> KDI (in Ref. 6; BAA02968). SQ SEQUENCE 359 AA; 41061 MW; 35FC856F53E911A6 CRC64; MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLLAGLAS LPAIIHRNVF FIENTNITVC AFHYESQNST LPIGLGLTKN ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFK IIMAIVLFFF FSWIPHQIFT FLDVLIQLGI IRDCRIADIV DTAMPITICI AYFNNCLNPL FYGFLGKKFK RYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSDNVSSSTK KPAPCFEVE //