Lafontaine lab :: Publications

2012

Folding of the SAM-I riboswitch: A tale with a twist.
Eschbach SH, St-Pierre P, Penedo JC, Lafontaine DA.
RNA Biology, in press.

2011

Constitutive regulatory activity of an evolutionary-excluded riboswitch variant.
Tremblay R, Lemay JF, Blouin S, Mulhbacher J, Bonneau E, Legault P, Dupont P, Penedo JC, Lafontaine DA.
The Journal of Biological Chemistry, 286:27406-15, 2011.

New insights into riboswitch regulation mechanisms.
Bastet L, Dubé A, Massé E, Lafontaine DA.
Molecular Microbiology, 80:1148-54, 2011.

Molecular insights into the ligand-controlled organization of the SAM-I riboswitch.
Heppell B, Blouin S, Dussault AM, Mulhbacher J, Ennifar E, Penedo JC, Lafontaine DA.
Nature Chem Biol, 7:384-92, 2011.

Comparative study between transcriptionally- and translationally-acting adenine riboswitches reveals key differences in riboswitch regulatory mechanisms.
Lemay JF, Desnoyers G, Blouin S, Heppell B, Bastet L, St-Pierre P, Massé E, Lafontaine DA.
PLoS Genetics, 7:e1001278, 2011.

Folding of the lysine riboswitch: importance of peripheral elements for transcriptional regulation.
Blouin S, Chinnappan R, Lafontaine DA.
Nucleic Acids Res, 39:3373-87, 2011.

2010

Novel riboswitch ligand analogs as selective inhibitors of guanine-related metabolic pathways.
Mulhbacher J, Brouillette E, Allard M, Fortier LC, Malouin F, Lafontaine DA.
PLoS Pathogens, 6:e1000865, 2010.

Therapeutic applications of ribozymes and riboswitches.
Mulhbacher J, St-Pierre P, Lafontaine DA.
Curr Opin Pharmacol., 10:551-6, 2010.

Small RNA-mediated regulation at the level of transcript stability.
Caron MP, Lafontaine DA, Massé E.
RNA Biol., 7:140-4, 2010.

Riboswitch structure: an internal residue mimicking the purine ligand.
Delfosse V, Bouchard P, Bonneau E, Dagenais P, Lemay JF, Lafontaine DA, Legault P.
Nucleic Acids Res, 38:32057-68, 2010.

2009

Functional studies of DNA-protein interactions using FRET techniques.
Blouin S, Craggs T, Lafontaine DA, Penedo JC.
Methods Mol Biol, 543:475-502, 2009.

Molecular Basis of RNA-Mediated Gene Regulation on the Adenine Riboswitch by Single-Molecule Approaches.
Lemay JF, Mulhbacher J, Penedo JC, Lafontaine DA.
Methods Mol Biol, 540:65-76, 2009.

Application of Fluorescence Measurements for Characterization of Riboswitch-Ligand Interactions.
Heppell B, Mulhbacher J, Penedo JC, Lafontaine DA.
Methods Mol Biol, 540:25-37, 2009.

Riboswitches: Ancient and Promising Genetic Regulators.
Blouin S, Mulhbacher J, Penedo JC, Lafontaine DA.
ChemBioChem, 10:400-16, 2009.

2008

Natural Functional Nucleic Acids: Ribozymes and Riboswitches.
Tremblay R, Mulhbacher J, Blouin S, Penedo JC, Lafontaine DA.
(2008). Functional Nucleic Acids for Analytical Applications (Li Y. and Yi L., Eds.), Springer, New-York, NY.

Folding of the SAM Aptamer is Determined by the Formation of a K-turn-dependent Pseudoknot.
Heppell B, Lafontaine DA.
Biochemistry, 47:1490-9, 2008.

2007

Ligand recognition determinants of guanine riboswitches.
Mulhbacher J, Lafontaine DA.
Nucleic Acids Research, 35:5568-5580, 2007.

A loop-loop interaction and a K-turn motif located in the lysine aptamer domain are important for the riboswitch gene regulation control.
Blouin S, Lafontaine DA.
RNA, 13:1256-1267, 2007.

Core requirements of the adenine riboswitch aptamer for ligand binding.
Lemay JF, Lafontaine DA.
RNA, 13:339-350, 2007.

2006

Folding of the adenine riboswitch.
Lemay JF, Penedo C, Tremblay R, Lilley DMJ, Lafontaine DA.
Chemistry & Biology, 13:857-68, 2006.

Le riborégulateur adénine: Un nouveau mode de régulation génétique.
Lemay JF, Lafontaine DA.
Médecine/Sciences, 22:1053-60, 2006.

2002

The global structure of the VS ribozyme.
Lafontaine DA, Norman DG, Lilley DM.
EMBO J., 21:2461-71, 2002.

Functional group requirements in the probable active site of the VS ribozyme
Lafontaine DA, Wilson TJ, Zhao ZY, Lilley DM
J Mol Biol., 323:23-34, 2002.

Folding and catalysis by the VS ribozyme.
Lafontaine DA, Norman DG, Lilley DM.
Biochimie, 84:889-96, 2002.

The structure and active site of the Varkud satellite ribozyme.
Lafontaine DA, Norman DG, Lilley DM.
Biochem Soc Trans., Nov;30(Pt 6):1170-5, 2002.

2001

Structure, folding and activity of the VS ribozyme: importance of the 2-3-6 helical junction.
Lafontaine DA, Norman DG, Lilley DM.
EMBO J., 20:1415-24, 2001.

The A730 loop is an important component of the active site of the VS ribozyme.
Lafontaine DA, Wilson TJ, Norman DG, Lilley DM.
J Mol Biol., 312:663-74, 2001.

2000

Nucleotides -1 to -4 of hepatitis delta ribozyme substrate increase the specificity of ribozyme cleavage.
Deschenes P, Lafontaine DA, Charland S, Perreault JP.
Antisense Nucleic Acid Drug Dev., 10:53-61, 2000.

1999

Presence of a coordinated metal ion in a trans-acting antigenomic delta ribozyme.
Lafontaine DA, Ananvoranich S, Perreault JP.
Nucleic Acids Res., 27:3236-43, 1999.

Mutational analysis of the antigenomic trans-acting delta ribozyme: the alterations of the middle nucleotides located on the P1 stem.
Ananvoranich S, Lafontaine DA, Perreault JP.
Nucleic Acids Res., 27:1473-9, 1999.

The viroid and viroid-like RNA database.
Lafontaine DA, Deschenes P, Bussiere F, Poisson V, Perreault JP.
Nucleic Acids Res., 27(1):186-7, 1999.

1998

Kinetic analysis of delta ribozyme cleavage.
Mercure S, Lafontaine D, Ananvoranich S, Perreault JP.
Biochemistry, 37:16975-82, 1998.

Identification of a Crohn's disease specific transcript with potential as a diagnostic marker.
Lafontaine DA, Mercure S, Perreault JP.
Gut, 42:878-82, 1998.

The viroid and viroid-like RNA database.
Lafontaine DA, Mercure S, Poisson V, Perreault JP.
Nucleic Acids Res., 26(1):190-1, 1998.

1997

Update of the viroid and viroid-like sequence database: addition of a hepatitis delta virus RNA section.
Lafontaine D, Mercure S, Perreault JP.
Nucleic Acids Res., 25(1):123-5, 1997.

1996

Compilation and analysis of viroid and viroid-like RNA sequences.
Mercure S, Lafontaine D, Ananvoranich S, Perreault JP.
Nucleic Acids Res., 24:1793-8, 1996.

1995

Intra- and intermolecular nonenzymatic ligations occur within transcripts derived from the peach latent mosaic viroid.
Lafontaine D, Beaudry D, Marquis P, Perreault JP.
Virology, 212:705-9, 1995.